| Round 1 | ||||||
|---|---|---|---|---|---|---|
| 19:45 Thursday 10.11.2011 | Worcester | 14 - 23 |  Stade Francais | 8,121 |  Dudley Phillips | Sixways |
| 20:30 Thursday 10.11.2011 | Toulon | 53 - 22 |  Padova | 1,095 |  Neil Hennessey | Stade Pierre Rajon |
| 19:00 Friday 11.11.2011 | Perpignan | 15 - 12 |  Exeter | 11,336 |  Peter Allan | Stade Aime Giral |
| 14:30 Saturday 12.11.2011 | Prato | 3 - 33 |  Dragons | 2,000 |  Mathieu Raynal | Stadio Lungobisenzio |
| 15:00 Saturday 12.11.2011 | Rovigo | 10 - 43 |  Bayonne | 900 |  Andy Macpherson | Stadio Mario Battaglini |
| 15:00 Saturday 12.11.2011 | Newcastle | 27 - 19 |  Lyon | 3,533 |  James Jones | Kingston Park |
| 16:00 Saturday 12.11.2011 | La Vila | 10 - 50 |  Agen | 2,500 |  Stefano Penne | Villajoyosa Stadium |
| 18:30 Saturday 12.11.2011 | Brive | 26 - 18 |  Sale | 5,500 |  Carlo Damasco | Stade Amedee-Domenech |
| 20:45 Saturday 12.11.2011 | Bordeaux | 14 - 47 |  Wasps | 16,953 |  Leighton Hodges | Stade Chaban Delmas |
| 15:00 Sunday 13.11.2011 | Bucharest Wolves | 34 - 7 |  Crociati | 1,000 |  Cedric Marchat | Stadium Arcul de Triumf |
| Round 2 | ||||||
| 19:45 Thursday 17.11.2011 | Dragons | 23 - 13 | Perpignan | 5,160 |  Neil Paterson | Rodney Parade |
| 20:30 Thursday 17.11.2011 | Bayonne | 20 - 3 | Bordeaux | 10,300 | James Jones | Stade Jean Dauger |
| 19:00 Friday 18.11.2011 | Stade Francais | 49 - 3 | Bucharest Wolves | 5,800 |  Luke Pearce | Stade Sebastien Charlety |
| 19:45 Friday 18.11.2011 | Sale | 59 - 6 | La Vila | 4,910 |  Alan Falzone | Edgeley Park |
| 15:00 Saturday 19.11.2011 | Exeter | 68 - 0 | Prato | 5,937 |  Laurent Cardona | Sandy Park |
| 15:00 Saturday 19.11.2011 | Padova | 3 - 34 | Newcastle | 1,900 | Dudley Phillips | Stadio Plebiscito |
| 20:30 Saturday 19.11.2011 | Crociati | 3 - 34 | Worcester | 300 |  Andrew McMenemy | Stadio XXV Aprile |
| 20:55 Saturday 19.11.2011 | Lyon | 19 - 26 | Toulon | 7,615 | Peter Allan | Matmut Stadium |
| 15:00 Sunday 20.11.2011 | Wasps | 38 - 7 | Rovigo | 4,225 | Neil Hennessey | Adams Park |
| 18:00 Sunday 20.11.2011 | Agen | 8 - 29 | Brive | 5,177 | Leighton Hodges | Stade Armandie |
| Round 3 | ||||||
| 19:45 Thursday 08.12.2011 | Newcastle | 6 - 3 | Toulon | 5,579 |  Peter Fitzgibbon | Kingston Park |
| 20:30 Thursday 08.12.2011 | Agen | 14 - 29 | Sale | 3,117 | Peter Allan | Stade Armandie |
| 19:00 Friday 09.12.2011 | Perpignan | 54 - 20 | Prato | 6,300 | Luke Pearce | Stade Aime Giral |
| 15:00 Saturday 10.12.2011 | Rovigo | 7 - 31 | Bordeaux | 800 | Leighton Hodges | Stadio Mario Battaglini |
| 16:00 Saturday 10.12.2011 | Crociati | 0 - 57 | Stade Francais | 1,000 | Neil Hennessey | Stadio XXV Aprile |
| 16:00 Saturday 10.12.2011 | La Vila | 18 - 47 | Brive | 1,000 |  David Wilkinson | Stadio Beltrametti |
| 17:00 Saturday 10.12.2011 | Lyon | 31 - 16 | Padova | 6,169 | Andy Macpherson | Matmut Stadium |
| 20:45 Saturday 10.12.2011 | Bayonne | 19 - 11 | Wasps | 11,876 | Dudley Phillips | Stade Jean Dauger |
| 15:00 Sunday 11.12.2011 | Bucharest Wolves | 13 - 24 | Worcester | 2,000 |  Marius Mitrea | Stadium Arcul de Triumf |
| 17:45 Sunday 11.12.2011 | Exeter | 18 - 6 | Dragons | 5,944 | Carlo Damasco | Sandy Park |
| Round 4 | ||||||
| 19:45 Thursday 15.12.2011 | Wasps | 25 - 11 | Bayonne | 4,350 | Neil Paterson | Adams Park |
| 20:00 Thursday 15.12.2011 | Brive | 38 - 13 | La Vila | 3,500 | Marius Mitrea | Stade Amedee-Domenech |
| 20:30 Thursday 15.12.2011 | Stade Francais | 45 - 3 | Crociati | 2,500 | Andy Macpherson | Stade Sebastien Charlety |
| 19:00 Friday 16.12.2011 | Bordeaux | 15 - 10 | Rovigo | 2,000 | Luke Pearce | Stade Andre-Moga |
| 14:30 Saturday 17.12.2011 | Prato | 13 - 30 | Perpignan | 1,500 | James Jones | Stadio Lungobisenzio |
| 15:00 Saturday 17.12.2011 | Padova | 3 - 43 | Lyon | 1,000 | Andrew McMenemy | Stadio Plebiscito |
| 15:00 Saturday 17.12.2011 | Worcester | 57 - 13 | Bucharest Wolves | 6,700 | Stefano Penne | Sixways |
| 20:45 Saturday 17.12.2011 | Toulon | 36 - 10 | Newcastle | 13,264 | Peter Allan | Stade Felix Mayol |
| 15:00 Sunday 18.12.2011 | Sale | 41 - 21 | Agen | 4,915 | Dudley Phillips | Edgeley Park |
| 17:45 Sunday 18.12.2011 | Dragons | 19 - 23 | Exeter | 5,137 | Mathieu Raynal | Rodney Parade |
| Round 5 | ||||||
| 20:15 Thursday 12.01.2012 | Bordeaux | 6 - 12 | Bayonne | 2,900 | Carlo Damasco | Stade Andre-Moga |
| 20:00 Friday 13.01.2012 | Brive | 50 - 13 | Agen | 3,500 | Luke Pearce | Stade Amedee-Domenech |
| 14:00 Saturday 14.01.2012 | Bucharest Wolves | 13 - 34 | Stade Francais | 1,074 | Marius Mitrea | Stadium Arcul de Triumf |
| 14:30 Saturday 14.01.2012 | Prato | 10 - 50 | Exeter | 1,050 | Cedric Marchat | Stadio Lungobisenzio |
| 15:00 Saturday 14.01.2012 | Worcester | 55 - 10 | Crociati | 4,531 | Andy Macpherson | Sixways |
| 15:00 Saturday 14.01.2012 | Rovigo | 11 - 32 | Wasps | 1,200 | Laurent Cardona | Stadio Mario Battaglini |
| 16:00 Saturday 14.01.2012 | La Vila | 10 - 69 | Sale | 2,000 | Andrew McMenemy | Villajoyosa Stadium |
| 20:55 Saturday 14.01.2012 | Perpignan | 27 - 13 | Dragons | 10,414 | Peter Allan | Stade Aime Giral |
| 15:30 Sunday 15.01.2012 | Newcastle | 43 - 0 | Padova | 2,831 | Neil Hennessey | Kingston Park |
| 18:30 Sunday 15.01.2012 | Toulon | 29 - 10 | Lyon | 14,121 | James Jones | Stade Felix Mayol |
| Round 6 | ||||||
| 19:45 Thursday 19.01.2012 | Sale | 9 - 19 | Brive | 6,955 | Peter Allan | Edgeley Park |
| 20:45 Thursday 19.01.2012 | Agen | 62 - 7 | La Vila | 2,169 | Marius Mitrea | Stade Armandie |
| 15:00 Saturday 21.01.2012 | Crociati | 13 - 26 | Bucharest Wolves | 250 | David Wilkinson | Stadio XXV Aprile |
| 15:00 Saturday 21.01.2012 | Lyon | 21 - 13 | Newcastle | 7,115 | Carlo Damasco | Matmut Stadium |
| 15:00 Saturday 21.01.2012 | Padova | 6 - 50 | Toulon | 2,000 | Andy Macpherson | Stadio Plebiscito |
| 15:00 Saturday 21.01.2012 | Exeter | 31 - 14 | Perpignan | 7,966 |  John Lacey | Sandy Park |
| 15:00 Saturday 21.01.2012 | Dragons | 45 - 16 | Prato | 4,736 | Andrew McMenemy | Rodney Parade |
| 20:45 Saturday 21.01.2012 | Stade Francais | 33 - 10 | Worcester | 6,693 | Leighton Hodges | Stade Sebastien Charlety |
| 15:00 Sunday 22.01.2012 | Wasps | 36 - 13 | Bordeaux | 4,809 | Neil Hennessey | Adams Park |
| 16:00 Sunday 22.01.2012 | Bayonne | 92 - 6 | Rovigo | 5,000 | James Jones | Stade Jean Dauger |
| Quarter-Final | ||||||
| 20:45 Thursday 05.04.2012 | Stade Francais | 22 - 17 | Exeter | 4,693 | Peter Fitzgibbon | Stade Sebastien Charlety |
| 20:45 Friday 06.04.2012 | Toulon | 37 - 8 |  Harlequins | 12,762 |  George Clancy | Stade Felix Mayol |
| 12:30 Saturday 07.04.2012 | Wasps | 23 - 26 |  Biarritz | 4,308 | John Lacey | Adams Park |
| 20:15 Sunday 08.04.2012 | Brive | 15 - 11 |  Scarlets | 7,850 |  Wayne Barnes | Stade Amedee-Domenech |
| Semi-Final | ||||||
| 20:55 Friday 27.04.2012 | Toulon | 32 - 29 | Stade Francais | 12,404 |  Alain Rolland | Stade Felix Mayol |
| 16:00 Saturday 28.04.2012 | Biarritz | 19 - 0 | Brive | 8,927 | George Clancy | Parc Aguilera |
| Final | ||||||
| 20:00 Friday 18.05.2012 | Biarritz | 21 - 18 | Toulon | 9,376 | Wayne Barnes | Twickenham Stoop |